A small signaling molecule auxin plays a key role in regulating plant organogenesis. In Arabidopsis, there is the complex feedback signaling network that involves at least 29 auxin-responsive proteins. To address this complexity, The laboratory of Dr. Wabnik @PlantDynamics lab transplanted an auxin-responsive feedback circuit responsible for plant organogenesis into yeast. By generating dynamic microfluidic conditions controlling gene expression, protein degradation, and DNA binding affinity, we illuminate principles underlying feedback signal processing in hormone-driven gene expression. In particular, our study reveals the regulatory mode shift between stimuli counting and rapid signal integration that is context-dependent. Overall, this work @CBGP offers mechanistic insights into dynamic auxin response interplay through synthetic biology, thereby offering instructions for engineering plant architecture.