Plants are constantly exposed to a multitude of different stresses, including drought, heat, and salinity, which drove them to establish appropriate responses to withstand. However, environmental stresses are assumed to intensify, due to the currently occurring global climate change. The consequential aggravation of the abiotic stresses are assumed to have largely detrimental effects on plant growth and development and, therefore, put global food security in jeopardy. For the given reason, it is necessary to extend our understanding of the molecular mechanisms that govern abiotic stress responses in plants. Herein, boosting our knowledge on the ways by which plants adjust their growth and stress response programs is of paramount importance, as this may lead to novel perspectives that can pave the way to increase agricultural productivity in a sustainable manner. In the presented review article, we provide a detailed overview of different facets of the crosstalk between the antagonistic plant hormones abscisic acid (ABA) and auxin, two phytohormones that are the main drivers of plant stress responses, on the one hand, and plant growth, on the other.