EPIGENETIC REGULATION OF AGRONOMIC TRAITS

Principal Investigator: Pedro Crevillen Lomas - Ramón y Cajal fellow

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Personnel:

Epigenetics, the study of heritable changes in gene function that take place without alterations in the DNA sequence, is a relevant topic in Biology nowadays. Epigenetic mechanisms are crucial for the proper development of plants. It is now possible to exploit epigenetic variation to obtain novel crops varieties in a more rational and efficient way. This natural epigenetic variation was exploited unconsciously during the domestication of many crops.

The best example of epigenetic regulation in pants is the regulation of flowering time in the model plant Arabidopsis thaliana. Arabidopsis belongs to the Brassicaceae family, which includes several important vegetable crops like cauliflower, broccoli, mustards, etc.; and oilseed crops like rapeseed, which is the third source of vegetable oil worldwide.

Flowering is a key agronomic trait for the production of fruits and seeds. A better understanding of the regulatory mechanism that control flowering time would allow us to increase crop yield. Nevertheless, the knowledge of the regulatory mechanism that control flowering time in Brassica crops is scarce.

Our research line focuses on the study of the epigenetic regulation of flowering time in an oliseed Brassica rapa cultivar. We are using mutant tilling lines together with epigenetics approaches (ChIP-seq and RNA-seq) to characterize the role of key epigenetic factors that controls flowering time. This is the first step towards the characterization of the epigenetic regulation of other agronomic traits in B. rapa, and in related Brassica crops like B. napus (rapeseed, canola).

Funding:
  • REGULACION EPIGENETICA DEL TIEMPO DE FLORACION EN CULTIVOS OLEAGINOSOS DE BRASSICA (2016-2018) Programa Estatal de I+D+i Orientada a los Retos de la Sociedad (BIO2015-68031-R)
  • Ayuda Contrato Ramón y Cajal (RYC-2103-14689)
 
 

Representative Publications

Gómez-Zambrano, Á; Crevillén, P; Franco-Zorrilla, JM; López, JA; Moreno-Romero, J; Roszak, P; Santos-González, J; Jurado, S; Vázquez, J; Köhler, C; Solano, R; Piñeiro, M; Jarillo, JA. 2018. "Arabidopsis SWC4 binds DNA and recruits the SWR1 complex to modulate histone H2A.Z deposition at key regulatory genes". Molecular Plant. DOI: 10.1016/j.molp.2018.03.014".

Crevillén, P; Yang, H; Cui, X; Greeff, C; Trick, M; Qiu, Q; Cao, X; Dean, C. 2014. "Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state". Nature. DOI: 10.1038/nature13722".

Crevillén, P; Sonmez, C; Wu, Z; Dean, C. 2013. "A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization". EMBO Journal. DOI: 10.1038/emboj.2012.324".

Castrillo, G; Sánchez-Bermejo, E; de Lorenzo, L; Crevillén, P; Fraile-Escanciano, A; TC, M; Mouriz, A; Catarecha, P; Sobrino-Plata, J; Olsson, S; Leo Del Puerto, Y; Mateos, I; Rojo, E; Hernández, LE; Jarillo, JA; Piñeiro, M; Paz-Ares, J; Leyva, A. 2013. "WRKY6 transcription factor restricts arsenate uptake and transposon activation in Arabidopsis". Plant Cell. DOI: tpc.113.114009 [pii] 10.1105/tpc.113.114009".

 

Centre for Plant Biotechnology and Genomics UPM – INIA Parque Científico y Tecnológico de la U.P.M. Campus de Montegancedo
Autopista M-40, Km 38 - 28223 Pozuelo de Alarcón (Madrid) Tel.: +34 91 4524900 ext. 1806 / +34 91 3364539 Fax: +34 91 7157721. Location and Contact

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