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Plant viral nanoparticles as important components in tissue bioengineering

Tissue bioengineering is progressively filling up important biomedical and food-related niches, such as organ and tissue regeneration, the generation of therapeutic models, and synthetic fabrication of meat and fish, among others. There are still quite a few technological aspects to be developed in order to get full implementation, thus related research activity is notably increasing. In the case of fundamentally fibrous tissues such as nerves, tendons, blood vessels, bones and muscles, a central goal consists of the fabrication of hydrogel filaments serving as scaffolds for the culture of cells aimed to purposes of tissue bioengineering. In this BIOFABRICATION article, a collaboration between the group ‘Plant Virus Biotechnology’ of the CBGP, led by Dr. Fernando Ponz, and research groups of Tecnológico de Monterrey (México) and the University of Connecticut (USA), the usefulness of viral nanoparticles derived from Turnip mosaic virus (TuMV) for the culture and bioengineering of murine myoblasts is shown. Incorporating TuMV into the cell culture system allowed an increment in the metabolic activity of the cell-seeded fibers, strengthened cell attachment, improved cell alignment, and promoted the generation of structures that resembled natural mammal muscle tissue. Future functionalizations of the viral nanoparticles will probably improve their role in the process even further.

Original Paper:

Frías-Sánchez, A.I., Quevedo-Moreno, D.A., Samandari, M., Negrete, J.A.T., Sánchez-Rodríguez, V.H., González-Gamboa, I., Ponz, F., Alvarez, M.M., Santiago, G.T. de 2021. Biofabrication of muscle fibers enhanced with plant viral nanoparticles using surface chaotic flows. Biofabrication. DOI: 10.1088/1758-5090/abd9d7

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