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Viral nanoparticles as new tool for the hard diagnosis of autoinmune diseases

Viral nanoparticles are increasingly used in different biotechnological and biomedical areas. In this case, nanoparticles derived from Turnip mosaic virus (TuMV) allowed the detection of alterations in autoantibody levels against Hsp60, a mitochondrial chaperonin involved in inflammatory processed, which were non-detectable so far with conventional methodology. Thanks to this hypersensitive detection system, correlations between autoantibody levels and an inflammatory status have been established in an animal model of the inflammatory bowel disease (IBD).

Deployment of this kind of molecular tools derived from plant viruses should allow the development of new biological models, leading to new therapeutic and diagnostic (theranostic) targets for these diseases which could improve the prognosis of patients in the future.

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Original Paper:

Yuste-Calvo, C., López-Santalla, M., Zurita, L., Cruz-Fernández, C.F., Sánchez, F., Garín, M.I., Ponz, F. 2019. Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection. Nanomaterials 9, 1438. DOI: 10.3390/nano9101438

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