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Development of a new system for detection of antibodies against SARS-CoV-2 by researchers from the CBGP

SARS-CoV-2 virus is tha infectious agent causing the COVID-19 pandemic, which has swept across the whole world during these last two years, rendering more than 195 millions of infected people and more than 4 millions of deaths.

Researchers from UPM belonging to both Plant Allergens (CBGP) and Optics, Photonics and Biophotonics (CTB) groups has jointly developed an innovative system for the detection of specific antibodies against the virus, present in serum and saliva human samples.

The detection of specific antibodies against the virus allows to determine the exposure of patients to the virus, regardless that they have developed clinical symptoms or not. This feature is crucial in order to, not only deploy an adequate public health response towards pandemic control, but also to clasify patients according to the antibodies profile and quantity detected in their samples.

The system developed by UPM researchers allows the simultaneous detection of different antibodies:

-IgM: antibodies associated to an early immune response, characteristic of the first days after exposure to the virus.

-IgG: antibodies associated to an advanced immune response, present in patients' samples in the mid and long term.

-IgA: antibodies characteristic of the immune response associated to the mucose, especially relevant towards the use of saliva as sample.

The advantges brought by this system are numerous. Among them, it is important to remark tha ability of distinguishing the stage of the infection and the possibility of using fast and easy to obtain samples towards its later analysis.

The detection system is based on the use of diagnostic kits containing a viral protein (Spike) and a detection platform based on photonic technology.

Besides that, the results obtained along its technical validation have been compared to a very well established technique in the diagnostic routine (ELISA), rendering encouraging conclusions in terms of efficacy of the system and its potential implementation along clinical routine.

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Original Paper:

Murillo, A.M.M., Tomé-Amat, J., Ramírez, Y., Garrido-Arandia, M., Valle, L.G., Hernández-Ramírez, G., Tramarin, L., Herreros, P., Santamaría, B., Díaz-Perales, A., Holgado, M. 2021. Developing an optical interferometric detection method based biosensor for the detection of detecting specific SARS-CoV-2 immunoglobulins in serum and saliva, and their corresponding ELISA correlation. Sensors and Actuators B: Chemical 130394. DOI: 10.1016/j.snb.2021.130394

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