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The ligands transported by allergenic Lipid Transfer Proteins (LTPs) mimic human inflammatory mediators

Plant Lipid Transfer Proteins (LTPs) cause food allergies. In this work, carried out by Dr. Araceli Díaz Perales's group, it has been discovered that the native ligand transported by allergenic LTPs would be mimicking a human inflammatory mediator: sphingosine-1-phosphate. This fact could explain why LTPs are associated with severe allergic responses.

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Original Paper:

Gonzalez-Klein, Z., Cuevas-Zuviria, B., Wangorsch, A., Hernandez-Ramirez, G., Pazos-Castro, D., Oeo-Santos, C., Romero-Sahagun, A., Pacios, L.F., Tome-Amat, J., Scheurer, S., Diaz-Perales, A., Garrido-Arandia, M. 2021. The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866, 158928. DOI: 10.1016/j.bbalip.2021.158928

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