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Jasmonate and auxin perception: how plants keep F-boxes in check

Ubiquitination and subsequent degradation of specific substrates play an essential role in plant hormone signaling. For instance, ubiquitination is required to activate signaling responses to jasmonate (JA) and auxin, two important phytohormones that regulate plant defense and developmental responses. The conjugation of ubiquitin to a substrate is facilitated by the E1 activating, E2 conjugating and the substrate-specifying E3 ligase. The most prevalent type of E3 ligase in plants is the Cullin-RING ligase (CRL)-type with F-box proteins (FBPs) as the substrate recognition component. The activity of these SKP-Cullin-F-box (SCF) complexes needs to be tightly regulated in time and place. Here, we review the regulation of SCF function in plants on multiple levels, with a focus on the auxin and jasmonate SCF-type receptor complexes. We particularly discuss the relevance of protein-protein interactions and posttranslational modifications as mechanisms to keep SCF functioning under control. Additionally, we highlight the unique property of SCFTIR1/AFB and SCFCOI1to recognize substrates by forming co-receptor complexes. Finally, we explore how engineered selective agonists can be used to study and uncouple the outcomes of the complex auxin and jasmonate signaling networks that are governed by these FBPs.


Original Paper:

Williams, C., Fernández-Calvo, P., Colinas, M., Pauwels, L., Goossens, A. 2019. Jasmonate and auxin perception: how plants keep F-boxes in check. Journal of Experimental Botany erz272. DOI: 10.1093/jxb/erz272

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